The intestinal mucosal barrier, also referred to as intestinal barrier, refers to the property of the intestinal mucosa that ensures adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients. The separation it provides between the body and the gut prevents the uncontrolled translocation of luminal contents into the body proper. Its role in protecting the mucosal tissues and circulatory system from exposure to pro-inflammatory molecules, such as microorganisms, toxins, and antigens is vital for the maintenance of health and well-being.[1][2][3] Intestinal mucosal barrier dysfunction has been implicated in numerous health conditions such as: food allergies, microbial infections, irritable bowel syndrome, inflammatory bowel disease, celiac disease, metabolic syndrome, non-alcoholic fatty liver disease, diabetes, and septic shock.[3][4][5]
- ^ Turner, JR (November 2009). "Intestinal mucosal barrier function in health and disease". Nat Rev Immunol. 9 (11): 799–809. doi:10.1038/nri2653. PMID 19855405. S2CID 205490916.
- ^ Lee, Sung Hee (2015-01-01). "Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases". Intestinal Research. 13 (1): 11–18. doi:10.5217/ir.2015.13.1.11. ISSN 1598-9100. PMC 4316216. PMID 25691839.
- ^ a b Sánchez de Medina, Fermín; Romero-Calvo, Isabel; Mascaraque, Cristina; Martínez-Augustin, Olga (2014-12-01). "Intestinal inflammation and mucosal barrier function". Inflammatory Bowel Diseases. 20 (12): 2394–2404. doi:10.1097/MIB.0000000000000204. ISSN 1536-4844. PMID 25222662. S2CID 11434730.
- ^ Cite error: The named reference
Groschwitz1was invoked but never defined (see the help page). - ^ Yan, Lei; Yang, Chunhui; Tang, Jianguo (2013-08-25). "Disruption of the intestinal mucosal barrier in Candida albicans infections". Microbiological Research. 168 (7): 389–395. doi:10.1016/j.micres.2013.02.008. ISSN 1618-0623. PMID 23545353.