Invasin

inverse autotransporter invasin
Identifiers
OrganismYersinia enterocolitica
Symbolinv
Entrez77327691
PDB1CWV
RefSeq (Prot)WP_263696614.1
UniProtP19196
Other data
ChromosomeGenomic: 1.75 - 1.75 Mb
Search for
StructuresSwiss-model
DomainsInterPro

Invasins are a class of bacterial proteins associated with the penetration of pathogens into host cells.[1] Invasins play a role in promoting entry during the initial stage of infection.[2][3]

In 2007, Als3 was identified as a fungal invasion allowing Candida albicans to infect host cells.[4]

Invasin is a small membrane bound protein that enables the infiltration of cultured mammalian cells by enteric bacteria. The cellular entry of invasin is facilitated through the binding of multiple β1 chain integrins.[5] The interplay between invasin and β1 integrins initiates a reconfiguration of the cytoskeleton in the target cell, culminating in the creation of a groove and the internalization of bacteria through endosomes by the cell. Invasin is expressed inYersinia enterocolitica and Yersinia pseudotuberculosis because of its outermembrane being chromosomally encoded.[6] Invasin demonstrates a significantly enhanced binding affinity to β1 integrins compared to the natural ligands of the receptor. More precisely, it forms a robust attachment to the α5β1 integrin, typically employed by fibronectin, exhibiting roughly 100 times greater strength. This heightened binding capability arises from structural disparities between the two proteins. The extracellular region of invasin adopts a rod-like configuration, with dimensions measuring approximately 180 Å by 30 Å by 30 Å.[7]

  1. ^ "Invasin". Stedman’s Medical Dictionary. Wolters Kluwer Health.
  2. ^ Isberg RR, Voorhis DL, Falkow S (August 1987). "Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells". Cell. 50 (5): 769–778. doi:10.1016/0092-8674(87)90335-7. PMID 3304658. S2CID 3125395.
  3. ^ Pepe JC, Miller VL (July 1993). "Yersinia enterocolitica invasin: a primary role in the initiation of infection". Proceedings of the National Academy of Sciences of the United States of America. 90 (14): 6473–6477. Bibcode:1993PNAS...90.6473P. doi:10.1073/pnas.90.14.6473. PMC 46954. PMID 8341658.
  4. ^ Phan QT, Myers CL, Fu Y, Sheppard DC, Yeaman MR, Welch WH, et al. (March 2007). "Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells". PLOS Biology. 5 (3): e64. doi:10.1371/journal.pbio.0050064. PMC 1802757. PMID 17311474.
  5. ^ "Invasin: Yersinia enterocolitica". UniProt. P19196. Retrieved 2023-11-28.
  6. ^ Boyd AP, Cornelis GR (2001). "Yersinia". Principles of Bacterial Pathogenesis. pp. 227–264. doi:10.1016/B978-012304220-0/50007-8. ISBN 978-0-12-304220-0. Invasin (Inv) is a chromosomally encoded outer membrane protein that is expressed in both Y. enterocolitica and Y. pseudotuberculosis.
  7. ^ Palumbo RN, Wang C (January 2006). "Bacterial invasin: structure, function, and implication for targeted oral gene delivery". Current Drug Delivery. 3 (1): 47–53. doi:10.2174/156720106775197475. PMID 16472093.