An ion-selective electrode (ISE), also known as a specific ion electrode (SIE), is a simple membrane-based potentiometric device which measures the activity of ions in solution.[1] It is a transducer (or sensor) that converts the change in the concentration of a specific ion dissolved in a solution into an electrical potential. The voltage is theoretically dependent on the logarithm of the ionic activity, according to the Nernst equation. Ion-selective electrodes are used in analytical chemistry and biochemical/biophysical research, where measurements of ionic concentration in an aqueous solution are required.[2]