Clinical data | |
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Trade names | Atrovent, Apovent, Ipraxa, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a618013 |
License data | |
Pregnancy category |
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Routes of administration | Inhalation, intranasal |
Drug class | Anticholinergic (muscarinic antagonist) |
ATC code | |
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Pharmacokinetic data | |
Protein binding | 0–9% in vitro |
Metabolism | Liver |
Onset of action | 15–30 minutes |
Elimination half-life | 2 hours |
Duration of action | 3–5 hours |
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CAS Number |
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PubChem CID | |
IUPHAR/BPS | |
DrugBank |
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ChemSpider | |
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KEGG | |
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ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.040.779 |
Chemical and physical data | |
Formula | C20H30BrNO3 |
Molar mass | 412.368 g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Ipratropium bromide, sold under the brand name Atrovent among others, is a type of anticholinergic medication which is applied by different routes: inhaler, nebulizer, or nasal spray, for different reasons.[1][2]
The inhalant opens up the medium and large airways in the lungs.[3][4] It is used to treat the symptoms of chronic obstructive pulmonary disease (COPD) and asthma.[3] It is used by inhaler or nebulizer.[3] Onset of action is typically within 15 to 30 minutes and lasts for three to five hours.[3]
The nasal spray prevents the glands in the nose from producing large amounts of fluid.[5][6] It is used to treat rhinorrhea (runny nose) caused by allergic rhinitis, nonallergic rhinitis,[5] and the common cold.[7][2] It is used by metered-dose manual pump spray. Onset of action is within an hour.[7]
Common side effects of inhalant use include dry mouth, cough, inflammation of the airways,[3] and shortness of breath.[8] Potentially serious side effects include urinary retention, worsening spasms of the airways, and a severe allergic reaction.[3] It appears to be safe in pregnancy and breastfeeding.[3][9] Ipratropium is a short-acting muscarinic antagonist,[10] which works by causing smooth muscles to relax.[3]
Common side effects of nasal spray may include headache, dry nose, dry mouth or throat, nasal or throat irritation, nosebleeds, bad taste in mouth, nausea, dizziness, or constipation.[7] Potentially serious side effects are unusual, but include severe allergic reaction, eye pain or change in vision, or urinary retention. It is considered safe during pregnancy, but it can pass into breast milk and may harm a nursing baby.[11]
Ipratropium bromide was patented in 1966, and approved for medical use in 1974.[12] It is on the World Health Organization's List of Essential Medicines, the most important medicines needed in a health system.[13] Ipratropium is available as a generic medication.[3] In 2021, it was the 269th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[14][15]
Ipratropium nasal spray is no longer sold under the brand name Atrovent, just the generic. The FDA has found Atrovent was not withdrawn from sale for reasons of safety or effectiveness.[16]
Nasal anticholinergics such as ipratropium bromide 0.03% are effective in controlling rhinorrhea, but do not relief other nasal symptoms. They block muscarinic receptors, leading to a decrease in the parasympathetic function.
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