Irene Syrikaina (Greek: Εἰρήνη Συρίκαινα) was the third Empress-consort of Manuel I of Trebizond. She may be the same Irene Syrikaina whom Michael Panaretos mentions was stoned to death in September 1332 in the purges that followed Basil Megas Komnenos's accession to the throne.[1]