Iron(III) citrate

Iron(III) citrate

One of several ferric citrate complexes[1]
Names
IUPAC name
iron(3+) 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.020.488 Edit this at Wikidata
UNII
  • InChI=1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3
    Key: NPFOYSMITVOQOS-UHFFFAOYSA-K
  • C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Fe+3]
Properties
C6H5FeO7
Molar mass 244.944 g·mol−1
Appearance dark orange-red brown solid[2]
~5 g/L in water
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ferric citrate or iron(III) citrate describes any of several complexes formed upon binding any of the several conjugate bases derived from citric acid with ferric ions. Most of these complexes are orange or red-brown. They contain two or more Fe(III) centers.[3]

Ferric citrates contribute to the metabolism of iron by some organisms. Citrates, which are released by plant roots and by some microorganisms, can solubilize iron compounds in the soil. For example ferric hydroxide reacts with citrates to give form soluble complexes. This solubilization provides a pathway for the absorption of the ferric ions by various organisms.[4]

Ferric citrate is used in medicine to regulate the blood levels of iron in patients with chronic kidney disease on dialysis. It acts by forming an insoluble compound with phosphate present in the diet and thus minimizing its uptake by the digestive system.[5]

  1. ^ Cite error: The named reference shweky was invoked but never defined (see the help page).
  2. ^ Sigma-Aldrich: Product Specification - Iron(III) citrate, technical grade. Accessed on 2017-03-09.
  3. ^ Cite error: The named reference nona was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference fuzzy was invoked but never defined (see the help page).
  5. ^ Lewis, Julia B.; Sika, Mohammed; Koury, Mark J.; Chuang, Peale; Schulman, Gerald; Smith, Mark T.; Whittier, Frederick C.; Linfert, Douglas R.; Galphin, Claude M.; Athreya, Balaji P.; Nossuli, A. Kaldun Kaldun; Chang, Ingrid J.; Blumenthal, Samuel S.; Manley, John; Zeig, Steven; Kant, Kotagal S.; Olivero, Juan Jose; Greene, Tom; Dwyer, Jamie P.; Collaborative Study Group (2015). "Ferric Citrate Controls Phosphorus and Delivers Iron in Patients on Dialysis". Journal of the American Society of Nephrology. 26 (2): 493–503. doi:10.1681/ASN.2014020212. PMC 4310662. PMID 25060056.