| Islands of Calleja | |
|---|---|
 Islands of Calleja of rat brain stained in blue. Denoted under IC abbreviation. | |
| Details | |
| Part of | Ventral Striatum |
| Artery | Anterior cerebral artery anterior communicating artery middle cerebral artery |
| Identifiers | |
| Latin | insulae olfactoriae, insula callejae |
| Acronym(s) | ISC or IClj |
| MeSH | D020670 |
| NeuroNames | 276 |
| NeuroLex ID | birnlex_1113 |
| FMA | 61888 |
| Anatomical terms of neuroanatomy | |
The islands of Calleja (Spanish: [kaˈʎexa]; IC, ISC, or IClj) are a group of neural granule cells located within the ventral striatum in the brains of most animals. This region of the brain is part of the limbic system, where it aids in the reinforcing effects of reward-like activities. Within most species, the islands are specifically located within the olfactory tubercle; however, in primates, these islands are located within the nucleus accumbens, the reward center of the brain, since the olfactory tubercle has practically disappeared in the brains of primates.[1] Both of these structures have been implicated in the processing of incentives as well as addictions to drugs.[2] Projections to and from the islands supplement this knowledge with their involvement in the reward pathways for both cocaine and amphetamines.[3]
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- ^ De Marchis S, Fasolo A, Puche AC. 2004. Subventricular zone-derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice. Journal of Comparative Neurology 476:290-300