JARID1B

KDM5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MA5, 2MNY, 2MNZ, 5A1F, 5A3N, 5A3P, 5A3T, 5A3W, 5FPL, 5FPU, 5FV3, 5FZ6, 5FUP, 5FUN, 5FZK, 5FYZ, 5FZ7, 5FZ9, 5FYU, 5FZB, 5FZC, 5FYT, 5FZ0, 5FYY, 5FZ1, 5FZ3, 5FZL, 5FZA, 5FZ4
Identifiers
Aliases	KDM5B, CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1, lysine demethylase 5B, MRT65
External IDs	OMIM: 605393; MGI: 1922855; HomoloGene: 48448; GeneCards: KDM5B; OMA:KDM5B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,808,487 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,563,023 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; ganglionic eminence; ; ventricular zone; ; epithelium of colon; ; testicle; ; gonad; ; skin of thigh; ; cartilage tissue;
	Top expressed in
	Rostral migratory stream; ; spermatocyte; ; maxillary prominence; ; mandibular prominence; ; spermatid; ; molar; ; internal carotid artery; ; ganglionic eminence; ; abdominal wall; ; Gonadal ridge;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; dioxygenase activity; metal ion binding; protein binding; oxidoreductase activity; histone demethylase activity; histone H3-tri/di/monomethyl-lysine-4 demethylase activity; sequence-specific double-stranded DNA binding; histone H3-methyl-lysine-4 demethylase activity; histone binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding; methylated histone binding;
Cellular component	nucleoplasm; nucleus; cytosol; histone methyltransferase complex;
Biological process	response to fungicide; positive regulation of mammary gland epithelial cell proliferation; regulation of transcription, DNA-templated; branching involved in mammary gland duct morphogenesis; uterus morphogenesis; rhythmic process; regulation of estradiol secretion; post-embryonic development; cellular response to fibroblast growth factor stimulus; transcription, DNA-templated; single fertilization; mammary duct terminal end bud growth; positive regulation of gene expression; lens fiber cell differentiation; negative regulation of transcription, DNA-templated; histone H3-K4 demethylation, trimethyl-H3-K4-specific; regulation of transcription by RNA polymerase II; histone H3-K4 demethylation; cellular response to leukemia inhibitory factor; chromatin organization; negative regulation of transcription by RNA polymerase II; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	10765
	75605
	ENSG00000117139
	ENSMUSG00000042207
	Q9UGL1
	Q80Y84
	NM_001314042; NM_006618; NM_001347591; NM_001399817
	NM_152895
	NP_001300971; NP_001334520; NP_006609
	NP_690855
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene.^[5]^[6]^[7] JARID1B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117139 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (August 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Research. 11 (8): 1327–34. doi:10.1101/gr.168801. hdl:10536/DRO/DU:30121320. PMID 11483573.
^ Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (August 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry. 40 (31): 9142–50. doi:10.1021/bi010476a. PMID 11478881.
^ "Entrez Gene: JARID1B jumonji, AT rich interactive domain 1B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117139 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11483573-5] Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (August 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Research. 11 (8): 1327–34. doi:10.1101/gr.168801. hdl:10536/DRO/DU:30121320. PMID 11483573.

[pmid11478881-6] Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (August 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry. 40 (31): 9142–50. doi:10.1021/bi010476a. PMID 11478881.

[entrez-7] "Entrez Gene: JARID1B jumonji, AT rich interactive domain 1B".

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