J chain

JCHAIN
Identifiers
Aliases	JCHAIN, IGCJ, JCH, IGJ, J chain, joining chain of multimeric IgA and IgM
External IDs	OMIM: 147790; MGI: 96493; HomoloGene: 16958; GeneCards: JCHAIN; OMA:JCHAIN - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	70,681,817 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	88,675,750 bp
RNA expression pattern
	Top expressed in
	rectum; ; jejunal mucosa; ; mucosa of sigmoid colon; ; pylorus; ; cecum; ; mucosa of transverse colon; ; appendix; ; epithelium of nasopharynx; ; duodenum; ; trachea;
	Top expressed in
	submandibular gland; ; spleen; ; duodenum; ; jejunum; ; Paneth cell; ; lymph node; ; tibiofemoral joint; ; tunica adventitia of aorta; ; mesenteric lymph nodes; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding; protein homodimerization activity; phosphatidylcholine binding; immunoglobulin receptor binding; single-stranded DNA binding; peptidoglycan binding; IgA binding; protein-macromolecule adaptor activity;
Cellular component	secretory IgA immunoglobulin complex; blood microparticle; hexameric IgM immunoglobulin complex; monomeric IgA immunoglobulin complex; dimeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; secretory dimeric IgA immunoglobulin complex; extracellular exosome; extracellular region; extracellular space;
Biological process	adaptive immune response; retina homeostasis; glomerular filtration; immune response; innate immune response; positive regulation of respiratory burst; receptor-mediated endocytosis; positive regulation of protein oligomerization; leukocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	3512
	16069
	ENSG00000132465
	ENSMUSG00000067149
	P01591
	P01592
	NM_144646
	NM_152839
	NP_653247
	NP_690052
	Wikidata
View/Edit Human	View/Edit Mouse

The Joining (J) chain is a protein component that links monomers of antibodies IgM and IgA to form polymeric antibodies capable of secretion.^[5] The J chain is well conserved in the animal kingdom, but its specific functions are yet to be fully understood. It is a 137 residue polypeptide,^[6] encoded by the IGJ gene.^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132465 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Levinson. Medical Microbiology and Immunology (11 ed.). McGraw Hill. pp. 405–6.
^ Schroeder H, Wald D, Greenspan N (2008). "Chapter 4: Immunoglobulins: Structure and Function". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 125–151. ISBN 978-0-7817-6519-0.
^ Max EE, McBride OW, Morton CC, Robinson MA (August 1986). "Human J chain gene: chromosomal localization and associated restriction fragment length polymorphisms". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5592–5596. Bibcode:1986PNAS...83.5592M. doi:10.1073/pnas.83.15.5592. PMC 386334. PMID 3016707.
^ Max EE, Korsmeyer SJ (April 1985). "Human J chain gene. Structure and expression in B lymphoid cells". The Journal of Experimental Medicine. 161 (4): 832–849. doi:10.1084/jem.161.4.832. PMC 2189063. PMID 2984306.
^ "Entrez Gene: IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132465 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Levinson_Microbiology-5] Levinson. Medical Microbiology and Immunology (11 ed.). McGraw Hill. pp. 405–6.

[Paul0804-6] Schroeder H, Wald D, Greenspan N (2008). "Chapter 4: Immunoglobulins: Structure and Function". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 125–151. ISBN 978-0-7817-6519-0.

[pmid3016707-7] Max EE, McBride OW, Morton CC, Robinson MA (August 1986). "Human J chain gene: chromosomal localization and associated restriction fragment length polymorphisms". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5592–5596. Bibcode:1986PNAS...83.5592M. doi:10.1073/pnas.83.15.5592. PMC 386334. PMID 3016707.

[pmid2984306-8] Max EE, Korsmeyer SJ (April 1985). "Human J chain gene. Structure and expression in B lymphoid cells". The Journal of Experimental Medicine. 161 (4): 832–849. doi:10.1084/jem.161.4.832. PMC 2189063. PMID 2984306.

[entrez-9] "Entrez Gene: IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]