James Noble may refer to:
- James Noble (actor) (1922–2016), American actor
- James Noble (American football) (born 1963), American football wide receiver
- James Noble (clergyman) (c. 1876–1941), Australian missionary
- James Noble (computer scientist), professor at Victoria University of Wellington, New Zealand
- James Noble (motocross), British motocross racer in 2008 FIM Motocross World Championship etc.
- James Noble (senator) (1785–1831), U.S. Senator from Indiana
- James Noble (geologist) (1800–1848), Scottish minister, antiquarian, geologist and fossil collector
- James Noble (Royal Navy officer) (1774–1851), British navy admiral
- James Campbell Noble (1846–1913), Scottish painter
- James H. Noble (1851–1912), American physician and politician