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John II Orsini (Italian: Giovanni II Orsini), also John Komnenos Doukas or Comnenus Ducas (Greek: Ἰωάννης Κομνηνός Δούκας, translit. Iōannēs Komnēnos Doukas), was a Greek-Italian noble man who rose to count palatine of Cephalonia from 1323 to 1324 and Despot of Epirus from 1323 to 1335.