John Vaughan, 2nd Viscount Lisburne (c.1695 – 15 January 1741) was a Welsh landowner and Whig politician who sat in the British House of Commons from 1727 to 1734. Apparently a heavy drinker, who kept several mistresses, he informally separated from his second wife in 1729 after she had an affair with his land agent. His spending badly impaired the financial soundness of his estate, and his brother and successor had to contend with the claims of Lisburne's wife's son on the estate.