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Jughead may refer to:
- Jughead (comic book), a comic book series
- Jughead Jones, a fictional character
- "Jughead" (Lost), a 2009n TV episode
- Jughead (search engine), for the Gopher protocol
- John Jughead Pierson, an American musician, writer, actor, and podcaster
- "Jughead", a song on the 1991 Prince album Diamonds and Pearls
- Jughead, a Mark 16 nuclear bomb due to be tested in the 1954 Castle Yankee thermonuclear bomb test