This article needs additional citations for verification. (January 2015) |
Names | |
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IUPAC name
3β,5,14-Trihydroxy-5β-card-20(22)-enolid-19-al
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Systematic IUPAC name
(1R,3aS,3bR,5aS,7S,9aS,9bS,11aR)-3a,5a,7-Trihydroxy-11a-methyl-1-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-9aH-cyclopenta[a]phenanthrene-9a-carbaldehyde | |
Other names
3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide,
Cymarigenen, Strophanthidin | |
Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.000.569 |
MeSH | Strophanthidin |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C23H32O6 | |
Molar mass | 404.5 g/mol |
Density | 1.43 g/mL |
Melting point | 169 °C (336 °F; 442 K) |
Boiling point | 620.7 °C (1,149.3 °F; 893.9 K) |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Toxic |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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k-Strophanthidin is a cardenolide found in species of the genus Strophanthus. It is the aglycone of k-strophanthin, an analogue of ouabain. k-strophanthin is found in the ripe seeds of Strophanthus kombé and in the lily Convallaria.
K-Strophantidin can be differentiated into[citation needed]:
Strophantidin is a cardiac glycoside which mechanism of action is similar to Digitalis, Ouabain and digitoxin. It specifically inhibits the membrane protein Na+/ K+ ATPase in muscle tissue (heart) which can lead to Ca2+ overload, diastolic dysfunction, arrhythmias and ultimately to heart failure and death. Native African tribes used Strophantidin among other toxins as arrow poison.