KAHA Ligation

The α-Ketoacid-Hydroxylamine (KAHA) Amide-Forming Ligation is a chemical reaction that is used to join two unprotected fragments in peptide synthesis.^[1]^[2] It is an alternative to the Native Chemical Ligation (NCL). KAHA Ligation was developed by Jeffrey W. Bode group at ETH Zürich (previously University of Pennsylvania).

^ Bode, Jeffrey W.; Fox, Ryan M.; Baucom, Kyle D. (2006). "Chemoselective Amide Ligations by Decarboxylative Condensations ofN-Alkylhydroxylamines and α-Ketoacids". Angewandte Chemie. 118 (8): 1270–1274. doi:10.1002/ange.200503991. ISSN 0044-8249.
^ Pusterla, Ivano; Bode, Jeffrey W. (2012). "The Mechanism of the α-Ketoacid-Hydroxylamine Amide-Forming Ligation". Angewandte Chemie. 124 (2): 528–531. doi:10.1002/ange.201107198. ISSN 0044-8249.

[BodeFox2006-1] Bode, Jeffrey W.; Fox, Ryan M.; Baucom, Kyle D. (2006). "Chemoselective Amide Ligations by Decarboxylative Condensations ofN-Alkylhydroxylamines and α-Ketoacids". Angewandte Chemie. 118 (8): 1270–1274. doi:10.1002/ange.200503991. ISSN 0044-8249.

[PusterlaBode2012-2] Pusterla, Ivano; Bode, Jeffrey W. (2012). "The Mechanism of the α-Ketoacid-Hydroxylamine Amide-Forming Ligation". Angewandte Chemie. 124 (2): 528–531. doi:10.1002/ange.201107198. ISSN 0044-8249.

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