KATNB1

KATNB1
Identifiers
AliasesKATNB1, KAT, LIS6, katanin regulatory subunit B1
External IDsOMIM: 602703; MGI: 1921437; HomoloGene: 4302; GeneCards: KATNB1; OMA:KATNB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005886

NM_028805

RefSeq (protein)

NP_005877

NP_083081

Location (UCSC)Chr 16: 57.74 – 57.76 MbChr 8: 95.81 – 95.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.[5][6]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.[6] KATNB1 is associated with microlissencephaly.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140854Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031787Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (May 1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719. S2CID 13583382.
  6. ^ a b "Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1".