KCNC1

KCNC1
Identifiers
Aliases	KCNC1, KV3.1, KV4, NGK2, EPM7, potassium voltage-gated channel subfamily C member 1
External IDs	OMIM: 176258; MGI: 96667; HomoloGene: 68134; GeneCards: KCNC1; OMA:KCNC1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	17,856,804 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,088,128 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; primary visual cortex; ; cerebellar vermis; ; right frontal lobe; ; Brodmann area 9; ; prefrontal cortex; ; Brodmann area 23; ; cingulate gyrus; ; anterior cingulate cortex; ; postcentral gyrus;
	Top expressed in
	cerebellar cortex; ; lobe of cerebellum; ; cerebellar vermis; ; substantia nigra; ; pontine nuclei; ; lateral geniculate nucleus; ; deep cerebellar nuclei; ; medial geniculate nucleus; ; medial vestibular nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; transmembrane transporter binding; voltage-gated ion channel activity; ion channel activity; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; kinesin binding; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential;
Cellular component	integral component of membrane; membrane; voltage-gated potassium channel complex; plasma membrane; neuronal cell body membrane; cell surface; soma; dendrite; neuron projection membrane; axolemma; dendrite membrane; calyx of Held; integral component of postsynaptic membrane; integral component of presynaptic membrane; axon;
Biological process	response to potassium ion; response to nerve growth factor; response to fibroblast growth factor; regulation of ion transmembrane transport; ion transport; protein tetramerization; globus pallidus development; cerebellum development; potassium ion transport; brain development; transmembrane transport; potassium ion transmembrane transport; response to amine; positive regulation of potassium ion transmembrane transport; response to auditory stimulus; response to light intensity; protein homooligomerization; positive regulation of ion transmembrane transport; response to toxic substance; regulation of potassium ion transmembrane transport; positive regulation of voltage-gated potassium channel activity; regulation of presynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	3746
	16502
	ENSG00000129159
	ENSMUSG00000058975
	P48547
	P15388
	NM_001112741; NM_004976
	NM_001112739; NM_008421
	NP_001106212; NP_004967
	NP_001106210; NP_032447
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily C member 1 is a protein that in humans is encoded by the KCNC1 gene.^[5]^[6]^[7]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129159 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058975 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ried T, Rudy B, Vega-Saenz de Miera E, Lau D, Ward DC, Sen K (Apr 1993). "Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15". Genomics. 15 (2): 405–11. doi:10.1006/geno.1993.1075. PMID 8449507.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b "Entrez Gene: KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129159 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058975 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8449507-5] Ried T, Rudy B, Vega-Saenz de Miera E, Lau D, Ward DC, Sen K (Apr 1993). "Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15". Genomics. 15 (2): 405–11. doi:10.1006/geno.1993.1075. PMID 8449507.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-7] "Entrez Gene: KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1".

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