KCNJ10

KCNJ10
Identifiers
Aliases	KCNJ10, BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME, potassium voltage-gated channel subfamily J member 10, potassium inwardly rectifying channel subfamily J member 10
External IDs	OMIM: 602208; MGI: 1194504; HomoloGene: 1689; GeneCards: KCNJ10; OMA:KCNJ10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,070,160 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,201,652 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; pars reticulata; ; subthalamic nucleus; ; nucleus accumbens; ; endothelial cell; ; caudate nucleus; ; pars compacta;
	Top expressed in
	deep cerebellar nuclei; ; mammillary body; ; medial vestibular nucleus; ; lateral geniculate nucleus; ; dorsal tegmental nucleus; ; medial dorsal nucleus; ; superior colliculus; ; substantia nigra; ; suprachiasmatic nucleus; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; potassium channel activity; voltage-gated ion channel activity; protein binding; ATP-activated inward rectifier potassium channel activity; ATP binding; G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; basolateral plasma membrane; presynapse;
Biological process	regulation of long-term neuronal synaptic plasticity; central nervous system myelination; regulation of membrane potential; regulation of ion transmembrane transport; ion transport; potassium ion transport; potassium ion homeostasis; potassium ion transmembrane transport; glutamate reuptake; regulation of resting membrane potential; oligodendrocyte development; visual perception; adult walking behavior; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3766
	16513
	ENSG00000177807
	ENSMUSG00000044708
	P78508
	Q9JM63
	NM_002241
	NM_001039484; NM_020269
	NP_002232
	NP_001034573
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-sensitive inward rectifier potassium channel 10 is a protein that in humans is encoded by the KCNJ10 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177807 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044708 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tada Y, Horio Y, Takumi T, Terayama M, Tsuji L, Copeland NG, et al. (November 1997). "Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1". Genomics. 45 (3): 629–30. doi:10.1006/geno.1997.4957. PMID 9367690.
^ Shuck ME, Piser TM, Bock JH, Slightom JL, Lee KS, Bienkowski MJ (January 1997). "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)". The Journal of Biological Chemistry. 272 (1): 586–93. doi:10.1074/jbc.272.1.586. PMID 8995301.
^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, et al. (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
^ "Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177807 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044708 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9367690-5] Tada Y, Horio Y, Takumi T, Terayama M, Tsuji L, Copeland NG, et al. (November 1997). "Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1". Genomics. 45 (3): 629–30. doi:10.1006/geno.1997.4957. PMID 9367690.

[pmid8995301-6] Shuck ME, Piser TM, Bock JH, Slightom JL, Lee KS, Bienkowski MJ (January 1997). "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)". The Journal of Biological Chemistry. 272 (1): 586–93. doi:10.1074/jbc.272.1.586. PMID 8995301.

[pmid16382105-7] Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, et al. (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.

[entrez-8] "Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10".

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