KCNJ16

KCNJ16
Identifiers
Aliases	KCNJ16, BIR9, KIR5.1, potassium voltage-gated channel subfamily J member 16, potassium inwardly rectifying channel subfamily J member 16, HKTD
External IDs	OMIM: 605722; MGI: 1314842; HomoloGene: 23112; GeneCards: KCNJ16; OMA:KCNJ16 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	70,135,608 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	110,918,794 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; kidney tubule; ; caput epididymis; ; dorsal motor nucleus of vagus nerve; ; glomerulus; ; thyroid gland; ; human kidney; ; metanephric glomerulus; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	human kidney; ; right kidney; ; epithelium of stomach; ; proximal tubule; ; lumbar subsegment of spinal cord; ; vestibular membrane of cochlear duct; ; otolith organ; ; utricle; ; deep cerebellar nuclei; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated ion channel activity; inward rectifier potassium channel activity; G-protein activated inward rectifier potassium channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3773
	16517
	ENSG00000153822
	ENSMUSG00000051497
	Q9NPI9
	Q9Z307
NM_001270422; NM_001291622; NM_001291623; NM_001291624; NM_001291625;
	NM_018658; NM_170741; NM_170742
	NM_001252207; NM_001252208; NM_001252209; NM_001252210; NM_010604
NP_001257351; NP_001278551; NP_001278552; NP_001278553; NP_001278554;
	NP_061128; NP_733937; NP_733938
	NP_001239136; NP_001239137; NP_001239138; NP_001239139; NP_034734
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the K_ir5.1 protein.^[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir5.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir5.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153822 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051497 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153822 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051497 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16".

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