KCNJ8

KCNJ8
Identifiers
Aliases	KCNJ8, KIR6.1, uKATP-1, potassium voltage-gated channel subfamily J member 8, potassium inwardly rectifying channel subfamily J member 8
External IDs	OMIM: 600935; MGI: 1100508; HomoloGene: 3654; GeneCards: KCNJ8; OMA:KCNJ8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,775,600 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,517,340 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium of left ventricle; ; apex of heart; ; body of pancreas; ; right lobe of liver; ; right auricle; ; gastric mucosa; ; pericardium; ; subcutaneous adipose tissue; ; visceral pleura;
	Top expressed in
	internal carotid artery; ; ascending aorta; ; molar; ; aortic valve; ; myocardium of ventricle; ; migratory enteric neural crest cell; ; digastric muscle; ; cardiac muscles; ; external carotid artery; ; interventricular septum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	voltage-gated ion channel activity; ATP binding; inward rectifier potassium channel activity; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; ATP-activated inward rectifier potassium channel activity; sulfonylurea receptor binding;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; voltage-gated potassium channel complex; plasma membrane; myofibril; mitochondrion; inward rectifying potassium channel; sarcolemma;
Biological process	response to exogenous dsRNA; kidney development; regulation of ion transmembrane transport; ion transport; heart development; response to lipopolysaccharide; defense response to virus; potassium ion transport; membrane repolarization during ventricular cardiac muscle cell action potential; potassium ion import across plasma membrane; ion transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3764
	16523
	ENSG00000121361
	ENSMUSG00000030247
	Q15842
	P97794
	NM_004982
	NM_008428; NM_001330363; NM_001330366
	NP_004973
	NP_001317292; NP_001317295; NP_032454
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein.^[5] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir6.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121361 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030247 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121361 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030247 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8".

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