KCNK12

KCNK12
Identifiers
Aliases	KCNK12, K2p12.1, THIK-2, THIK2, potassium two pore domain channel subfamily K member 12
External IDs	OMIM: 607366; MGI: 2684043; HomoloGene: 11107; GeneCards: KCNK12; OMA:KCNK12 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	47,570,985 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	88,105,422 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; trigeminal ganglion; ; spinal ganglia; ; inferior olivary nucleus; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; sural nerve; ; primary visual cortex;
	Top expressed in
	primary visual cortex; ; cerebellar cortex; ; superior frontal gyrus; ; embryo; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; anterior horn of spinal cord; ; olfactory bulb; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; voltage-gated ion channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; stabilization of membrane potential; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	56660
	210741
	ENSG00000184261
	ENSMUSG00000050138
	Q9HB15
	Q76M80
	NM_022055
	NM_199251
	NP_071338
	NP_954859
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K_2P12.1, is a potassium channel containing two pore-forming P domains.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184261 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050138 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184261 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050138 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11060316-5] Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.

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