KCNK13

KCNK13
Identifiers
Aliases	KCNK13, K2p13.1, THIK-1, THIK1, potassium two pore domain channel subfamily K member 13
External IDs	OMIM: 607367; MGI: 2384976; HomoloGene: 69351; GeneCards: KCNK13; OMA:KCNK13 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	90,185,853 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	100,028,941 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; monocyte; ; granulocyte; ; appendix; ; human kidney; ; right auricle; ; left lobe of thyroid gland; ; prefrontal cortex; ; right lobe of thyroid gland;
	Top expressed in
	secondary oocyte; ; stroma of bone marrow; ; primary oocyte; ; zygote; ; embryo; ; left lung lobe; ; superior frontal gyrus; ; deep cerebellar nuclei; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; voltage-gated ion channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; stabilization of membrane potential; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	56659
	217826
	ENSG00000152315
	ENSMUSG00000045404
	Q9HB14
	Q8R1P5
	NM_022054
	NM_001164426; NM_001164427; NM_146037
	NP_071337
	NP_001157898; NP_001157899; NP_666149
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K_2P13.1 is a potassium channel containing two pore-forming P domains.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045404 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152315 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045404 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11060316-5] Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

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