KCNK15

KCNK15
Identifiers
Aliases	KCNK15, K2p15.1, KCNK11, KCNK14, KT3.3, TASK-5, TASK5, dJ781B1.1, potassium two pore domain channel subfamily K member 15
External IDs	OMIM: 607368; MGI: 2675209; HomoloGene: 11179; GeneCards: KCNK15; OMA:KCNK15 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,752,313 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,701,666 bp
RNA expression pattern
	Top expressed in
	thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; left coronary artery; ; gonad; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; right uterine tube; ; testicle;
	Top expressed in
	cumulus cell; ; olfactory bulb; ; sternocleidomastoid muscle; ; cerebellar cortex; ; superior frontal gyrus; ; submandibular gland; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated ion channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; cardiac conduction; ion transport; stabilization of membrane potential; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	60598
	241769
	ENSG00000124249
	ENSMUSG00000035238
	Q9H427
	n/a
	NM_022358
	NM_001030292
	NP_071753
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 15 is a protein that in humans is encoded by the KCNK15 gene.^[5]^[6]^[7]^[8]

This gene encodes K_2P15.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P15.1 has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035238 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim D, Gnatenco C (Jun 2001). "TASK-5, a new member of the tandem-pore K(+) channel family". Biochem Biophys Res Commun. 284 (4): 923–30. doi:10.1006/bbrc.2001.5064. PMID 11409881.
^ Vega-Saenz de Miera E, Lau DH, Zhadina M, Pountney D, Coetzee WA, Rudy B (Jun 2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1". J Neurophysiol. 86 (1): 130–42. doi:10.1152/jn.2001.86.1.130. PMID 11431495. S2CID 14855672.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK15 potassium channel, subfamily K, member 15".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035238 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11409881-5] Kim D, Gnatenco C (Jun 2001). "TASK-5, a new member of the tandem-pore K(+) channel family". Biochem Biophys Res Commun. 284 (4): 923–30. doi:10.1006/bbrc.2001.5064. PMID 11409881.

[pmid11431495-6] Vega-Saenz de Miera E, Lau DH, Zhadina M, Pountney D, Coetzee WA, Rudy B (Jun 2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1". J Neurophysiol. 86 (1): 130–42. doi:10.1152/jn.2001.86.1.130. PMID 11431495. S2CID 14855672.

[pmid16382106-7] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-8] "Entrez Gene: KCNK15 potassium channel, subfamily K, member 15".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]