KCNK16

KCNK16
Identifiers
Aliases	KCNK16, K2p16.1, TALK-1, TALK1, potassium two pore domain channel subfamily K member 16
External IDs	OMIM: 607369; MGI: 1921821; HomoloGene: 75328; GeneCards: KCNK16; OMA:KCNK16 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	39,322,968 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,319,267 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; body of pancreas; ; duodenum; ; body of stomach; ; fundus; ; left lobe of thyroid gland; ; ascending aorta; ; right lung; ; right lobe of thyroid gland; ; olfactory zone of nasal mucosa;
	Top expressed in
	islet of Langerhans; ; embryo; ; yolk sac; ; stomach; ; lip; ; hair follicle; ; skin of abdomen; ; lumbar spinal ganglion; ; skin of back; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; voltage-gated ion channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; potassium ion transmembrane transport; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	83795
	74571
	ENSG00000095981
	ENSMUSG00000023387
	Q96T55
	G5E845
	NM_001135105; NM_001135106; NM_001135107; NM_032115; NM_001363784
	NM_029006
	NP_001128577; NP_001128578; NP_001128579; NP_115491; NP_001350713
	NP_083282
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene.^[5]^[6] The protein encoded by this gene, K_2P16.1, is a potassium channel containing two pore-forming P domains.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095981 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023387 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (Mar 2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem Biophys Res Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
^ ^a ^b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095981 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023387 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11263999-5] Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (Mar 2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem Biophys Res Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

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