KCNK5

KCNK5
Identifiers
Aliases	KCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5
External IDs	OMIM: 603493; MGI: 1336175; HomoloGene: 2773; GeneCards: KCNK5; OMA:KCNK5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	39,229,475 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,231,877 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; mucosa of transverse colon; ; mucosa of ileum; ; oocyte; ; duodenum; ; human kidney; ; kidney tubule; ; secondary oocyte; ; jejunal mucosa; ; skin of leg;
	Top expressed in
	right kidney; ; proximal tubule; ; intestinal villus; ; human kidney; ; left colon; ; jejunum; ; lumbar spinal ganglion; ; pyloric antrum; ; morula; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated potassium channel activity; potassium channel activity; voltage-gated ion channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; excretion; ion transport; potassium ion transmembrane transport; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	8645
	16529
	ENSG00000164626
	ENSMUSG00000023243
	O95279
	Q9JK62
	NM_003740
	NM_021542
	NP_003731
	NP_067517
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.^[5]^[6]^[7]

This gene encodes K_2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164626 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023243 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem. 273 (47): 30863–9. doi:10.1074/jbc.273.47.30863. PMID 9812978.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164626 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023243 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9812978-5] Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem. 273 (47): 30863–9. doi:10.1074/jbc.273.47.30863. PMID 9812978.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-7] "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5".

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