KCNK6

KCNK6
Identifiers
Aliases	KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDs	OMIM: 603939; MGI: 1891291; HomoloGene: 31266; GeneCards: KCNK6; OMA:KCNK6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,332,076 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,931,940 bp
RNA expression pattern
	Top expressed in
	decidua; ; ectocervix; ; monocyte; ; right coronary artery; ; ascending aorta; ; myometrium; ; mucosa of transverse colon; ; vagina; ; smooth muscle tissue; ; parotid gland;
	Top expressed in
	fossa; ; skin of abdomen; ; right lobe of liver; ; epithelium of stomach; ; Paneth cell; ; parotid gland; ; condyle; ; stroma of bone marrow; ; mesenteric lymph nodes; ; umbilical cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inward rectifier potassium channel activity; voltage-gated ion channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; membrane; integral component of plasma membrane;
Biological process	regulation of resting membrane potential; potassium ion transport; regulation of ion transmembrane transport; cardiac conduction; ion transport; negative regulation of systemic arterial blood pressure; potassium ion transmembrane transport; regulation of systemic arterial blood pressure; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	9424
	52150
	ENSG00000099337
	ENSMUSG00000046410
	Q9Y257
	n/a
	NM_004823
	NM_001033525
	NP_004814; NP_004814.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.^[5]^[6]^[7]^[8]

This gene encodes K_2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099337 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046410 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.
^ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428. S2CID 84538070.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099337 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046410 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10075682-5] Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.

[pmid10393428-6] Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428. S2CID 84538070.

[pmid16382106-7] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-8] "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

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