KCNN1

KCNN1
Identifiers
Aliases	KCNN1, KCa2.1, SK1, SKCA1, hSK1, potassium calcium-activated channel subfamily N member 1
External IDs	OMIM: 602982; MGI: 1933993; HomoloGene: 37595; GeneCards: KCNN1; OMA:KCNN1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,000,080 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; amygdala; ; Region I of hippocampus proper; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; ganglionic eminence; ; putamen;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	small conductance calcium-activated potassium channel activity; calcium-activated potassium channel activity; calmodulin binding; protein heterodimerization activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; soma; plasma membrane; membrane; neuron projection;
Biological process	potassium ion transport; ion transport; potassium ion transmembrane transport; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	3780
	84036
	ENSG00000105642
	ENSMUSG00000002908
	Q92952
	Q9EQR3
	NM_002248
	NM_032397
	NP_002239
	NP_115773; NP_001350336; NP_001350337
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the K_Ca2.1 protein.^[4]

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The K_Ca2.1 protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. The KCNN1 gene is a member of the KCNN family of potassium channel genes.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105642 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KCNN1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105642 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: KCNN1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1".

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