KCNN2

KCNN2
Identifiers
Aliases	KCNN2, KCa2.2, SK2, SKCA2, SKCa 2, hSK2, potassium calcium-activated channel subfamily N member 2, DYT34, NEDMAB
External IDs	OMIM: 605879; MGI: 2153182; HomoloGene: 23150; GeneCards: KCNN2; OMA:KCNN2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	114,496,500 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	45,686,024 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; Region I of hippocampus proper; ; Brodmann area 23; ; middle temporal gyrus; ; gonad; ; testicle;
	Top expressed in
	adrenal gland; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; cerebellar cortex; ; subiculum; ; Region I of hippocampus proper; ; hippocampus proper; ; lateral geniculate nucleus; ; primary motor cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein domain specific binding; calcium-activated potassium channel activity; calmodulin binding; alpha-actinin binding; protein binding; small conductance calcium-activated potassium channel activity;
Cellular component	integral component of membrane; membrane; cell surface; soma; plasma membrane; Z discdkac; dendritic spine; neuron projection;
Biological process	ion transport; potassium ion transport; regulation of potassium ion transmembrane transport; potassium ion transmembrane transport; membrane repolarization during atrial cardiac muscle cell action potential;
	Sources:Amigo / QuickGO
Orthologs
	3781
	140492
	ENSG00000080709
	ENSMUSG00000054477
	Q9H2S1
	P58390
	NM_001278204; NM_021614; NM_170775; NM_001372233
	NM_080465; NM_001312905
	NP_001265133; NP_067627; NP_740721; NP_001359162
	NP_001299834; NP_536713
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a protein which in humans is encoded by the KCNN2 gene.^[5] KCNN2 is an ion channel protein also known as K_Ca2.2.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080709 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054477 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (December 2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.
^ "Entrez Gene: KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080709 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054477 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382103-5] Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (December 2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.

[entrez-6] "Entrez Gene: KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2".

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