KCNQ5

KCNQ5
Identifiers
Aliases	KCNQ5, Kv7.5, potassium voltage-gated channel subfamily Q member 5, MRD46
External IDs	OMIM: 607357; MGI: 1924937; HomoloGene: 28270; GeneCards: KCNQ5; OMA:KCNQ5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	73,198,853 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	22,032,166 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pons; ; Brodmann area 23; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; quadriceps femoris muscle; ; Brodmann area 46; ; vastus lateralis muscle; ; superior frontal gyrus;
	Top expressed in
	primary motor cortex; ; olfactory tubercle; ; nucleus accumbens; ; piriform cortex; ; sternocleidomastoid muscle; ; prefrontal cortex; ; temporal muscle; ; globus pallidus; ; digastric muscle; ; temporal lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; potassium channel activity; protein binding; voltage-gated ion channel activity; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; calmodulin binding;
Cellular component	membrane; clathrin coat; integral component of membrane; integral component of plasma membrane; voltage-gated potassium channel complex; plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	56479
	226922
	ENSG00000185760
	ENSMUSG00000028033
	Q9NR82
	Q9JK45
	NM_001160130; NM_001160132; NM_001160133; NM_001160134; NM_019842
	NM_001160139; NM_023872; NM_001310477
	NP_001153602; NP_001153604; NP_001153605; NP_001153606; NP_062816
	NP_001153611; NP_001297406; NP_076361
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.^[5]^[6]^[7]^[8]

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185760 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (Aug 2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J Biol Chem. 275 (29): 22395–400. doi:10.1074/jbc.M002378200. PMID 10787416.
^ Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (Sep 2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J Biol Chem. 275 (31): 24089–95. doi:10.1074/jbc.M003245200. PMID 10816588.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b "Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185760 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028033 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10787416-5] Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (Aug 2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J Biol Chem. 275 (29): 22395–400. doi:10.1074/jbc.M002378200. PMID 10787416.

[pmid10816588-6] Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (Sep 2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J Biol Chem. 275 (31): 24089–95. doi:10.1074/jbc.M003245200. PMID 10816588.

[pmid16382104-7] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-8] "Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5".

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