KCNS3

KCNS3
Identifiers
Aliases	KCNS3, KV9.3, potassium voltage-gated channel modifier subfamily S member 3
External IDs	OMIM: 603888; MGI: 1098804; HomoloGene: 20518; GeneCards: KCNS3; OMA:KCNS3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	18,361,616 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	11,201,057 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; visceral pleura; ; Skeletal muscle tissue of biceps brachii; ; retinal pigment epithelium; ; hair follicle; ; muscle of thigh; ; palpebral conjunctiva; ; gastrocnemius muscle; ; upper lobe of left lung;
	Top expressed in
	lumbar spinal ganglion; ; morula; ; olfactory epithelium; ; embryo; ; embryo; ; blastocyst; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; white adipose tissue; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; delayed rectifier potassium channel activity; voltage-gated ion channel activity; ion channel activity; potassium channel regulator activity; voltage-gated potassium channel activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; voltage-gated potassium channel complex; plasma membrane; cytosol;
Biological process	regulation of insulin secretion; regulation of ion transmembrane transport; ion transport; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	3790
	238076
	ENSG00000170745
	ENSMUSG00000043673
	Q9BQ31
	Q8BQZ8
	NM_001282428; NM_002252
	NM_001168564; NM_173417
	NP_001269357; NP_002243
	NP_001162036; NP_775593
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily S member 3 (Kv9.3) is a protein that in humans is encoded by the KCNS3 gene.^[5]^[6]^[7] KCNS3 gene belongs to the S subfamily of the potassium channel family.^[7] It is highly expressed in pulmonary artery myocytes,^[8]^[9]^[10] placenta,^[11] and parvalbumin-containing GABA neurons in brain cortex.^[12]^[13] In humans, single-nucleotide polymorphisms of the KCNS3 gene are associated with airway hyperresponsiveness,^[14] whereas decreased KCNS3 mRNA expression is found in the prefrontal cortex of patients with schizophrenia.^[13]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170745 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043673 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shepard AR, Rae JL (September 1999). "Electrically silent potassium channel subunits from human lens epithelium". The American Journal of Physiology. 277 (3): C412–C424. doi:10.1152/ajpcell.1999.277.3.C412. PMID 10484328.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3". Retrieved 19 June 2017.
^ Patel AJ, Lazdunski M, Honoré E (November 1997). "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes". The EMBO Journal. 16 (22): 6615–6625. doi:10.1093/emboj/16.22.6615. PMC 1170266. PMID 9362476.
^ Stocker M, Kerschensteiner D (July 1998). "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain". Biochemical and Biophysical Research Communications. 248 (3): 927–934. doi:10.1006/bbrc.1998.9072. PMID 9704029.
^ Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, et al. (November 2006). "Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (5): L993-1004. doi:10.1152/ajplung.00191.2005. PMID 16815889.
^ Fyfe GK, Panicker S, Jones RL, Wareing M (October 2012). "Expression of an electrically silent voltage-gated potassium channel in the human placenta". Journal of Obstetrics and Gynaecology. 32 (7): 624–629. doi:10.3109/01443615.2012.709288. PMID 22943705. S2CID 27217929.
^ Georgiev D, González-Burgos G, Kikuchi M, Minabe Y, Lewis DA, Hashimoto T (2012). "Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex". PLOS ONE. 7 (8): e43904. Bibcode:2012PLoSO...743904G. doi:10.1371/journal.pone.0043904. PMC 3427167. PMID 22937123.
^ ^a ^b Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, et al. (January 2014). "Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia". The American Journal of Psychiatry. 171 (1): 62–71. doi:10.1176/appi.ajp.2013.13040468. PMC 3947279. PMID 24170294.
^ Hao K, Niu T, Xu X, Fang Z, Xu X (April 2005). "Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness". Human Genetics. 116 (5): 378–383. doi:10.1007/s00439-005-1256-5. PMID 15714333. S2CID 20997775.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170745 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043673 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10484328-5] Shepard AR, Rae JL (September 1999). "Electrically silent potassium channel subunits from human lens epithelium". The American Journal of Physiology. 277 (3): C412–C424. doi:10.1152/ajpcell.1999.277.3.C412. PMID 10484328.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-7] "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3". Retrieved 19 June 2017.

[Patel1997-8] Patel AJ, Lazdunski M, Honoré E (November 1997). "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes". The EMBO Journal. 16 (22): 6615–6625. doi:10.1093/emboj/16.22.6615. PMC 1170266. PMID 9362476.

[Stocker1998-9] Stocker M, Kerschensteiner D (July 1998). "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain". Biochemical and Biophysical Research Communications. 248 (3): 927–934. doi:10.1006/bbrc.1998.9072. PMID 9704029.

[Fantozzi2006-10] Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, et al. (November 2006). "Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (5): L993-1004. doi:10.1152/ajplung.00191.2005. PMID 16815889.

[Fyfe2012-11] Fyfe GK, Panicker S, Jones RL, Wareing M (October 2012). "Expression of an electrically silent voltage-gated potassium channel in the human placenta". Journal of Obstetrics and Gynaecology. 32 (7): 624–629. doi:10.3109/01443615.2012.709288. PMID 22943705. S2CID 27217929.

[Georgiev2012-12] Georgiev D, González-Burgos G, Kikuchi M, Minabe Y, Lewis DA, Hashimoto T (2012). "Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex". PLOS ONE. 7 (8): e43904. Bibcode:2012PLoSO...743904G. doi:10.1371/journal.pone.0043904. PMC 3427167. PMID 22937123.

[Georgiev2014-13] Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, et al. (January 2014). "Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia". The American Journal of Psychiatry. 171 (1): 62–71. doi:10.1176/appi.ajp.2013.13040468. PMC 3947279. PMID 24170294.

[Hao2005-14] Hao K, Niu T, Xu X, Fang Z, Xu X (April 2005). "Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness". Human Genetics. 116 (5): 378–383. doi:10.1007/s00439-005-1256-5. PMID 15714333. S2CID 20997775.

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