KDM1A

KDM1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 2Z3Y, 2Z5U, 3ABT, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1, 4BAY, 4CZZ, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN, 5AFW, 5L3D, 5L3B, 5IT3, 5L3C, 4XBF
Identifiers
Aliases	KDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A
External IDs	OMIM: 609132; MGI: 1196256; HomoloGene: 32240; GeneCards: KDM1A; OMA:KDM1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 23,019,443 bp[1] End 23,083,689 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 68.8 cM Start 136,277,851 bp[2] End 136,330,034 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right testis left testis beta cell stromal cell of endometrium anterior pituitary right ovary right uterine tube left ovary Top expressed in urethra epithelium of urethra male urethra tail of embryo ganglionic eminence epithelium of male urethra female urethra Gonadal ridge epithelium of female urethra genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding telomeric repeat-containing RNA binding demethylase activity telomeric DNA binding flavin adenine dinucleotide binding p53 binding protein binding androgen receptor binding nuclear receptor coactivator activity histone H3-methyl-lysine-4 demethylase activity oxidoreductase activity chromatin binding histone deacetylase activity histone demethylase activity enzyme binding MRF binding transcription factor binding histone H3-methyl-lysine-9 demethylase activity Cellular component DNA repair complex nucleoplasm nucleus transcription regulator complex protein-containing complex Biological process regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of double-strand break repair via homologous recombination cellular response to UV histone H3-K4 demethylation regulation of transcription by RNA polymerase II negative regulation of DNA binding protein demethylation positive regulation of DNA-binding transcription factor activity blood coagulation negative regulation of protein binding negative regulation of DNA-binding transcription factor activity transcription, DNA-templated multicellular organism development negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of histone ubiquitination cellular response to gamma radiation negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II alternative mRNA splicing, via spliceosome cerebral cortex development positive regulation of cell size response to organic cyclic compound guanine metabolic process cellular response to cAMP positive regulation of chromatin binding histone deacetylation positive regulation of neuron projection development neuron maturation response to fungicide negative regulation of transcription by RNA polymerase II histone H3-K9 demethylation muscle cell development chromatin organization positive regulation of neuroblast proliferation negative regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation positive regulation of cold-induced thermogenesis positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23028 99982 Ensembl ENSG00000004487 ENSMUSG00000036940 UniProt O60341 Q6ZQ88 RefSeq (mRNA) NM_001009999 NM_015013 NM_001363654 NM_133872 NM_001347221 NM_001356567 RefSeq (protein) NP_001009999 NP_055828 NP_001350583 NP_001334150 NP_598633 NP_001343496 Location (UCSC) Chr 1: 23.02 – 23.08 Mb Chr 4: 136.28 – 136.33 Mb PubMed search [3] [4]
Wikidata
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Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene.^[5] LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysine 4 (H3K4). Other reported methylated lysine substrates such as histone H3K9 and TP53 have not been biochemically validated.^[6] This enzyme plays a critical role in oocyte growth, embryogenesis, hematopoiesis and tissue-specific differentiation.^[7] LSD1 was the first histone demethylase to be discovered though more than 30 have since been described.^[8]