KDM4A

KDM4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GF7, 2GFA, 2GP3, 2GP5, 2OQ6, 2OQ7, 2OS2, 2OT7, 2OX0, 2P5B, 2PXJ, 2Q8C, 2Q8D, 2Q8E, 2QQR, 2QQS, 2VD7, 2WWJ, 2YBK, 2YBP, 2YBS, 3NJY, 3PDQ, 3RVH, 3U4S, 4AI9, 4BIS, 4GD4, 4URA, 4V2V, 4V2W, 5D6X, 5F5I, 5A7S, 5F2S, 5A7N, 5A7Q, 5A7O, 5F2W, 5D6W, 5F32, 5FPV, 5A7P, 5A7W, 5F3I, 5A80, 5F37, 5F3E, 5F39, 5F3G, 5F3C, 5D6Y, 5FYC, 5FYI, 5FY8, 5FWE, 5ANQ, 5FYH
Identifiers
Aliases	KDM4A, JHDM3A, JMJD2, JMJD2A, TDRD14A, lysine demethylase 4A
External IDs	OMIM: 609764; MGI: 2446210; HomoloGene: 27780; GeneCards: KDM4A; OMA:KDM4A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,705,518 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	118,037,240 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; right adrenal cortex; ; mucosa of transverse colon; ; rectum; ; left adrenal gland; ; islet of Langerhans; ; stromal cell of endometrium; ; left adrenal cortex; ; smooth muscle tissue;
	Top expressed in
	hand; ; ventricular zone; ; granulocyte; ; molar; ; epithelium of small intestine; ; ganglionic eminence; ; neural layer of retina; ; foot; ; otolith organ; ; utricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	dioxygenase activity; metal ion binding; methylated histone binding; protein binding; histone H3-methyl-lysine-36 demethylase activity; oxidoreductase activity; ubiquitin protein ligase binding; histone H3-methyl-lysine-9 demethylase activity; zinc ion binding; histone demethylase activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding;
Cellular component	nucleoplasm; fibrillar center; cytosol; nucleus; pericentric heterochromatin; cytoplasm; histone methyltransferase complex;
Biological process	histone demethylation; regulation of transcription, DNA-templated; negative regulation of gene expression; transcription, DNA-templated; viral process; negative regulation of transcription, DNA-templated; negative regulation of autophagy; histone H3-K9 demethylation; histone H3-K36 demethylation; chromatin organization; negative regulation of transcription by RNA polymerase II; positive regulation of gene expression; cardiac muscle hypertrophy in response to stress; response to nutrient levels; positive regulation of neuron differentiation; negative regulation of astrocyte differentiation; negative regulation of cell death; negative regulation of histone H3-K9 trimethylation; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	9682
	230674
	ENSG00000066135
	ENSMUSG00000033326
	O75164
	Q8BW72
	NM_014663
	NM_001161823; NM_172382
	NP_055478
	NP_001155295; NP_759014
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000066135 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033326 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
^ "Entrez Gene: JMJD2A jumonji domain containing 2A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000066135 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033326 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid15138608-6] Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.

[entrez-7] "Entrez Gene: JMJD2A jumonji domain containing 2A".

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