KIRREL3

KIRREL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRY
Identifiers
Aliases	KIRREL3, KIRRE, MRD4, NEPH2, PRO4502, kin of IRRE like 3 (Drosophila), Kin of IRRE-like protein 3, kirre like nephrin family adhesion molecule 3
External IDs	OMIM: 607761; MGI: 1914953; HomoloGene: 57050; GeneCards: KIRREL3; OMA:KIRREL3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	127,003,460 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	35,036,716 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; nucleus accumbens; ; Brodmann area 23; ; prefrontal cortex; ; right frontal lobe; ; caudate nucleus; ; putamen; ; Brodmann area 9; ; endothelial cell; ; C1 segment;
	Top expressed in
	Rostral migratory stream; ; lobe of cerebellum; ; cerebellar vermis; ; nucleus accumbens; ; substantia nigra; ; lumbar subsegment of spinal cord; ; hand; ; dentate gyrus of hippocampal formation granule cell; ; inferior colliculi; ; otolith organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	dendritic shaft; integral component of membrane; extracellular region; axon; plasma membrane; membrane; dendrite;
Biological process	neuron projection morphogenesis; neuron migration; inter-male aggressive behavior; principal sensory nucleus of trigeminal nerve development; glomerulus morphogenesis; hippocampus development; homophilic cell adhesion via plasma membrane adhesion molecules; synapse assembly; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	84623
	67703
	ENSG00000149571
	ENSMUSG00000032036
	Q8IZU9
	Q8BR86
	NM_001161707; NM_001301097; NM_032531
	NM_001190911; NM_001190912; NM_001190913; NM_001190914; NM_026324
	NP_001155179; NP_001288026; NP_115920
	NP_001177840; NP_001177841; NP_001177842; NP_001177843; NP_080600
	Wikidata
View/Edit Human	View/Edit Mouse

Kin of IRRE-like protein 3 (KIRREL3) also known as kin of irregular chiasm-like protein 3 or NEPH2 is a protein that in humans is encoded by the KIRREL3 gene.^[5]

NEPH2 is a member of the NEPH protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). The NEPH proteins can interact with nephrin and CASK.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149571 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032036 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: kin of IRRE like 3 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149571 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032036 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: kin of IRRE like 3 (Drosophila)".

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