KLF1

KLF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L2I, 2MBH, 2N23
Identifiers
Aliases	KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF1
External IDs	OMIM: 600599; MGI: 1342771; HomoloGene: 4785; GeneCards: KLF1; OMA:KLF1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,884,422 bp[1] End 12,887,201 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 41.3 cM|8 C3 Start 85,628,557 bp[2] End 85,631,924 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone bone marrow blood bone marrow cells monocyte tibialis anterior muscle granulocyte ventricular zone gonad spleen Top expressed in fetal liver hematopoietic progenitor cell tibiofemoral joint human fetus spleen embryo body of femur bone marrow abdominal wall urethra female urethra More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding cis-regulatory region sequence-specific DNA binding metal ion binding nucleic acid binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated erythrocyte differentiation cellular response to peptide regulation of transcription, DNA-templated transcription, DNA-templated maternal process involved in female pregnancy regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10661 16596 Ensembl ENSG00000105610 ENSMUSG00000054191 UniProt Q13351 P46099 RefSeq (mRNA) NM_006563 NM_010635 RefSeq (protein) NP_006554 NP_034765 Location (UCSC) Chr 19: 12.88 – 12.89 Mb Chr 8: 85.63 – 85.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells.