KLF11

KLF11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PO4
Identifiers
Aliases	KLF11, FKLF, FKLF1, MODY7, TIEG2, Tieg3, Kruppel-like factor 11, Kruppel like factor 11
External IDs	OMIM: 603301; MGI: 2653368; HomoloGene: 2668; GeneCards: KLF11; OMA:KLF11 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 10,042,849 bp[1] End 10,054,836 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.3|12 8.49 cM Start 24,701,273 bp[2] End 24,712,788 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad skin of thigh testicle monocyte saphenous vein skin of hip gastric mucosa amniotic fluid abdominal fat Top expressed in zygote secondary oocyte superior cervical ganglion hand otolith organ utricle primary oocyte gastrula decidua right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol focal adhesion nuclear body Biological process positive regulation of apoptotic process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription involved in G1/S transition of mitotic cell cycle transcription, DNA-templated negative regulation of cell population proliferation apoptotic process cellular response to peptide regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8462 194655 Ensembl ENSG00000172059 ENSMUSG00000020653 UniProt O14901 Q8K1S5 RefSeq (mRNA) NM_001177716 NM_001177718 NM_003597 NM_178357 RefSeq (protein) NP_001171187 NP_001171189 NP_003588 NP_848134 Location (UCSC) Chr 2: 10.04 – 10.05 Mb Chr 12: 24.7 – 24.71 Mb PubMed search [3] [4]
Wikidata
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Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.^[5][6][7]

KLF11 is a mesoderm derived, zinc finger transcription factor in the Krüppel-like factor (KLF) family. It binds to SP1- like GC- rich sequences in epsilon and gamma globin gene promoters inhibiting cellular growth and causing apoptosis. In the regulation of genes, it is involved in cellular inflammation and differentiation, making it an essential factor in early embryonic development. This transcription factor binds to promoters of genes involved in cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism, specifically pancreatic beta cell function. Defects in KLF11 affect glucose metabolism, insulin transcription, insulin processing, and insulin secretion which cause type 2 diabetes in adults and maturity-onset diabetes of the young type 7. These types of diabetes are caused by KLF11 interacting with co-repressors in the pancreatic islet beta cells. KLF11 has recently been shown to be involved in endometriosis since it regulated the expression of extracellular matrix genes. Its absence in extracellular matrix genes created a more fibrogenic response by the tissue. This was proved by creating a “knockout” model. The experiment showed that the absence of KLF11 showed higher amounts of fibrosis indicating that it prevents the growth of endometriotic lesions and inhibits pathological scarring.

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