KLF15

KLF15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ENT
Identifiers
Aliases	KLF15, KKLF, Kruppel-like factor 15, Kruppel like factor 15
External IDs	OMIM: 606465; MGI: 1929988; HomoloGene: 8553; GeneCards: KLF15; OMA:KLF15 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 126,342,635 bp[1] End 126,357,408 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 90,439,558 bp[2] End 90,452,220 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland cardia lower lobe of lung sural nerve renal medulla gastric mucosa right lobe of liver inferior ganglion of vagus nerve ventral tegmental area external globus pallidus Top expressed in left lobe of liver lacrimal gland interventricular septum vestibular membrane of cochlear duct right kidney proximal tubule muscle of thigh masseter muscle parotid gland retinal pigment epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus Biological process regulation of gene expression glomerular visceral epithelial cell differentiation positive regulation of transcription, DNA-templated negative regulation of peptidyl-lysine acetylation glial cell differentiation cardiac muscle hypertrophy in response to stress regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II positive regulation of glucose import regulation of transcription by RNA polymerase II cellular glucose homeostasis response to insulin cellular response to peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28999 66277 Ensembl ENSG00000163884 ENSMUSG00000030087 UniProt Q9UIH9 Q9EPW2 RefSeq (mRNA) NM_014079 NM_023184 NM_001355668 RefSeq (protein) NP_054798 NP_075673 NP_001342597 Location (UCSC) Chr 3: 126.34 – 126.36 Mb Chr 6: 90.44 – 90.45 Mb PubMed search [3] [4]
Wikidata
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Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene^[5] in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.^[6]