KLF2

KLF2
Identifiers
Aliases	KLF2, LKLF, Kruppel-like factor 2, Kruppel like factor 2
External IDs	OMIM: 602016; MGI: 1342772; HomoloGene: 133978; GeneCards: KLF2; OMA:KLF2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,328,685 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	73,075,500 bp
RNA expression pattern
	Top expressed in
	urethra; ; vena cava; ; trachea; ; saphenous vein; ; gastric mucosa; ; granulocyte; ; nipple; ; pericardium; ; cardia; ; pylorus;
	Top expressed in
	granulocyte; ; right lung; ; ankle joint; ; right lung lobe; ; mesenteric lymph nodes; ; spleen; ; subcutaneous adipose tissue; ; ankle; ; endocardial cushion; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA-binding transcription factor activity; metal ion binding; protein binding; nucleic acid binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	cellular response to peptide; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; multicellular organism growth; cellular response to laminar fluid shear stress; positive regulation of transcription from RNA polymerase II promoter in response to stress; positive regulation of nitric oxide biosynthetic process; negative regulation of interleukin-6 production; cellular response to tumor necrosis factor; cellular response to organic cyclic compound; response to laminar fluid shear stress; in utero embryonic development; transcription, DNA-templated; positive regulation of transcription, DNA-templated; erythrocyte homeostasis; type I pneumocyte differentiation; cellular response to interleukin-1; cell morphogenesis; cellular response to cycloheximide; cellular response to hydrogen peroxide; erythrocyte maturation; positive regulation of transcription by RNA polymerase II; cellular response to fluid shear stress; negative regulation of transcription by RNA polymerase II; cellular stress response to acid chemical; negative regulation of sprouting angiogenesis; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10365
	16598
	ENSG00000127528
	ENSMUSG00000055148
	Q9Y5W3
	Q60843
	NM_016270; NM_006075; NM_016198
	NM_008452
	NP_057354
	NP_032478
	Wikidata
View/Edit Human	View/Edit Mouse

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19.^[5]^[6] It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127528 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kozyrev SV, Hansen LL, Poltaraus AB, Domninsky DA, Kisselev LL (Jun 1999). "Structure of the human CpG-island-containing lung Krüppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus". FEBS Lett. 448 (1): 149–52. Bibcode:1999FEBSL.448..149K. doi:10.1016/S0014-5793(99)00348-8. PMID 10217429. S2CID 20878426.
^ Wani MA, Conkright MD, Jeffries S, Hughes MJ, Lingrel JB (Sep 1999). "cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor". Genomics. 60 (1): 78–86. doi:10.1006/geno.1999.5888. PMID 10458913.
^ Pearson R; Fleetwood J; Eaton S; Crossley M; Bao S (2008). "Krüppel-like transcription factors: a functional family". Int J Biochem Cell Biol. 40 (10): 1996–2001. doi:10.1016/j.biocel.2007.07.018. PMID 17904406.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127528 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10217429-5] Kozyrev SV, Hansen LL, Poltaraus AB, Domninsky DA, Kisselev LL (Jun 1999). "Structure of the human CpG-island-containing lung Krüppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus". FEBS Lett. 448 (1): 149–52. Bibcode:1999FEBSL.448..149K. doi:10.1016/S0014-5793(99)00348-8. PMID 10217429. S2CID 20878426.

[pmid10458913-6] Wani MA, Conkright MD, Jeffries S, Hughes MJ, Lingrel JB (Sep 1999). "cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor". Genomics. 60 (1): 78–86. doi:10.1006/geno.1999.5888. PMID 10458913.

[Pearson-7] Pearson R; Fleetwood J; Eaton S; Crossley M; Bao S (2008). "Krüppel-like transcription factors: a functional family". Int J Biochem Cell Biol. 40 (10): 1996–2001. doi:10.1016/j.biocel.2007.07.018. PMID 17904406.

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