KLF4

KLF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WBS, 2WBU, 4M9E
Identifiers
Aliases	KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
External IDs	OMIM: 602253; MGI: 1342287; HomoloGene: 3123; GeneCards: KLF4; OMA:KLF4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.2 Start 107,484,852 bp[1] End 107,490,482 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B3|4 29.76 cM Start 55,527,143 bp[2] End 55,532,466 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip human penis mucosa of sigmoid colon synovial joint skin of arm skin of abdomen vulva jejunal mucosa mucosa of pharynx Top expressed in epithelium of stomach mucous cell of stomach skin of external ear conjunctival fornix left colon pyloric antrum intestinal villus umbilical cord cervix stria vascularis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding beta-catenin binding phosphatidylinositol 3-kinase regulator activity DNA-binding transcription factor activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding cis-regulatory region sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity protein binding nucleic acid binding double-stranded DNA binding promoter-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coregulator binding histone deacetylase binding Cellular component cytoplasm transcription regulator complex nucleoplasm chromatin nucleus Biological process negative regulation of chemokine (C-X-C motif) ligand 2 production epidermal cell differentiation cellular response to retinoic acid negative regulation of protein kinase B signaling negative regulation of muscle hyperplasia negative regulation of smooth muscle cell proliferation positive regulation of protein metabolic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of axon regeneration cellular response to peptide regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process response to retinoic acid somatic stem cell population maintenance cellular response to laminar fluid shear stress regulation of transcription by RNA polymerase II cell differentiation epidermis morphogenesis positive regulation of nitric oxide biosynthetic process cellular response to growth factor stimulus cellular response to organic cyclic compound post-embryonic hemopoiesis negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II response to organic substance negative regulation of gene expression negative regulation of response to cytokine stimulus transcription, DNA-templated negative regulation of DNA-binding transcription factor activity negative regulation of phosphatidylinositol 3-kinase signaling stem cell population maintenance negative regulation of cell migration involved in sprouting angiogenesis positive regulation of gene expression negative regulation of cell migration regulation of cell population proliferation post-embryonic camera-type eye development regulation of phosphatidylinositol 3-kinase activity positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of cell differentiation mesodermal cell fate determination negative regulation of heterotypic cell-cell adhesion negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity cellular response to cycloheximide negative regulation of inflammatory response fat cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation cellular response to hydrogen peroxide negative regulation of leukocyte adhesion to arterial endothelial cell positive regulation of core promoter binding cellular response to leukemia inhibitory factor negative regulation of angiogenesis pri-miRNA transcription by RNA polymerase II negative regulation of G1/S transition of mitotic cell cycle positive regulation of transcription, DNA-templated positive regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9314 16600 Ensembl ENSG00000136826 ENSMUSG00000003032 UniProt O43474 Q60793 RefSeq (mRNA) NM_001314052 NM_004235 NM_010637 RefSeq (protein) NP_001300981 NP_004226 NP_034767 Location (UCSC) Chr 9: 107.48 – 107.49 Mb Chr 4: 55.53 – 55.53 Mb PubMed search [3] [4]
Wikidata
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Krüppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors.^[5][6][7] KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer.^[8] It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2.^[6] It has two nuclear localization sequences that signals it to localize to the nucleus.^[9] In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

In humans, the protein is 513 amino acids, with a predicted molecular weight of approximately 55kDa, and is encoded by the KLF4 gene.^[10] The KLF4 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.^[11] KLF4 was first identified in 1996.^[12]