KLF7

KLF7
Identifiers
Aliases	KLF7, UKLF, Kruppel-like factor 7 (ubiquitous), Kruppel like factor 7
External IDs	OMIM: 604865; MGI: 1935151; HomoloGene: 2751; GeneCards: KLF7; OMA:KLF7 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	207,167,267 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	64,161,441 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; saphenous vein; ; ganglionic eminence; ; Achilles tendon; ; spinal ganglia; ; bone marrow cells; ; sural nerve; ; gonad; ; hair follicle; ; testicle;
	Top expressed in
	Rostral migratory stream; ; trigeminal ganglion; ; spinal ganglia; ; supraoptic nucleus; ; lumbar spinal ganglion; ; aortic valve; ; ascending aorta; ; barrel cortex; ; saccule; ; motor neuron;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription coactivator activity; zinc ion binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; axonogenesis; transcription, DNA-templated; dendrite morphogenesis; axon guidance; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of epidermal cell differentiation; regulation of insulin secretion; negative regulation of adipose tissue development; negative regulation of transcription by RNA polymerase II; glucose homeostasis; negative regulation of insulin secretion involved in cellular response to glucose stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8609
	93691
	ENSG00000118263
	ENSMUSG00000025959
	O75840
	Q99JB0
	NM_001270942; NM_001270943; NM_001270944; NM_003709
	NM_033563
	NP_001257871; NP_001257872; NP_001257873; NP_003700
	NP_291041
	Wikidata
View/Edit Human	View/Edit Mouse

Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.^[5]^[6]

This protein is a member of the Kruppel-like family of transcription factors.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118263 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025959 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KLF7 Kruppel-like factor 7 (ubiquitous)".
^ Matsumoto N, Laub F, Aldabe R, Zhang W, Ramirez F, Yoshida T, Terada M (October 1998). "Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors". The Journal of Biological Chemistry. 273 (43): 28229–37. doi:10.1074/jbc.273.43.28229. PMID 9774444.
^ Bieker JJ (September 2001). "Krüppel-like factors: three fingers in many pies". The Journal of Biological Chemistry. 276 (37): 34355–8. doi:10.1074/jbc.R100043200. PMID 11443140.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118263 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025959 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KLF7 Kruppel-like factor 7 (ubiquitous)".

[pmid9774444-6] Matsumoto N, Laub F, Aldabe R, Zhang W, Ramirez F, Yoshida T, Terada M (October 1998). "Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors". The Journal of Biological Chemistry. 273 (43): 28229–37. doi:10.1074/jbc.273.43.28229. PMID 9774444.

[pmid11443140-7] Bieker JJ (September 2001). "Krüppel-like factors: three fingers in many pies". The Journal of Biological Chemistry. 276 (37): 34355–8. doi:10.1074/jbc.R100043200. PMID 11443140.

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