KLK7

KLK7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QXG, 2QXH, 2QXI, 2QXJ, 3BSQ
Identifiers
Aliases	KLK7, PRSS6, SCCE, hK7, kallikrein related peptidase 7
External IDs	OMIM: 604438; MGI: 1346336; HomoloGene: 37998; GeneCards: KLK7; OMA:KLK7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,984,099 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,465,783 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; vulva; ; human penis; ; skin of arm; ; skin of thigh; ; skin of abdomen; ; nipple; ; skin of hip; ; mucosa of pharynx; ; body of tongue;
	Top expressed in
	lip; ; skin of external ear; ; basilar part of occipital bone; ; skin of back; ; esophagus; ; sphenoid bone; ; decidua; ; umbilical cord; ; basisphenoid; ; Meckel's cartilage;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; metalloendopeptidase activity;
Cellular component	extracellular region; epidermal lamellar body; extracellular space; secretory granule;
Biological process	positive regulation of antibacterial peptide production; extracellular matrix disassembly; proteolysis; epidermis development;
	Sources:Amigo / QuickGO
Orthologs
	5650
	23993
	ENSG00000169035
	ENSMUSG00000030713
	P49862; Q6DTY1
	Q91VE3
	NM_139277; NM_001207053; NM_001243126; NM_005046
	NM_011872
	NP_001193982; NP_001230055; NP_005037; NP_644806
	NP_036002
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene.^[5]^[6]^[7]^[8] KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE).^[9] It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169035 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030713 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference pmid8034709 was invoked but never defined (see the help page).
^ Cite error: The named reference pmid16800724 was invoked but never defined (see the help page).
^ Cite error: The named reference pmid16800723 was invoked but never defined (see the help page).
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Cite error: The named reference pmid1685827 was invoked but never defined (see the help page).
^ Cite error: The named reference pmid10974542 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169035 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030713 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8034709-5] Cite error: The named reference pmid8034709 was invoked but never defined (see the help page).

[pmid16800724-6] Cite error: The named reference pmid16800724 was invoked but never defined (see the help page).

[pmid16800723-7] Cite error: The named reference pmid16800723 was invoked but never defined (see the help page).

[entrez-8] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid1685827-9] Cite error: The named reference pmid1685827 was invoked but never defined (see the help page).

[pmid10974542-10] Cite error: The named reference pmid10974542 was invoked but never defined (see the help page).

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