KMT2C

KMT2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YSM, 2YUK, 3UVL, 4ERY, 5F59, 5F6K
Identifiers
Aliases	KMT2C, HALR, MLL3, lysine methyltransferase 2C, KLEFS2
External IDs	OMIM: 606833; MGI: 2444959; HomoloGene: 46480; GeneCards: KMT2C; OMA:KMT2C - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	152,436,644 bp
RNA expression pattern
	Top expressed in
	oocyte; ; caput epididymis; ; skin of arm; ; pancreatic epithelial cell; ; corpus epididymis; ; cardiac muscle tissue of right atrium; ; Achilles tendon; ; sural nerve; ; bone marrow cells; ; seminal vesicula;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; protein binding; histone methyltransferase activity (H3-K4 specific); metal ion binding; acyltransferase activity; histone-lysine N-methyltransferase activity; RNA binding; transcription coactivator activity; histone binding;
Cellular component	MLL3/4 complex; nucleus; nucleoplasm; histone methyltransferase complex;
Biological process	histone lysine methylation; methylation; regulation of transcription, DNA-templated; transcription, DNA-templated; histone H3-K4 methylation; regulation of megakaryocyte differentiation; chromatin organization; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	58508
	231051
	ENSG00000055609
	n/a
	Q8NEZ4
	Q8BRH4
	NM_021230; NM_170606
	NM_001081383; NM_177283
	NP_733751
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.^[4]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000055609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
^ "Entrez Gene: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000055609 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-4] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.

[entrez-5] "Entrez Gene: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3".

[1]

[2]

[3]

[4]

[5]