KNT-127

KNT-127
Names
IUPAC name
(1R,14S,15R)-25-Methyl-4,25-diazahexacyclo[13.7.3.01,14.03,12.05,10.017,22]pentacosa-3,5,7,9,11,17(22),18,20-octaene-14,20-diol
Identifiers
3D model (JSmol)
  • InChI=1S/C24H24N2O2/c1-26-9-8-23-14-21-17(10-16-4-2-3-5-20(16)25-21)13-24(23,28)22(26)11-15-6-7-18(27)12-19(15)23/h2-7,10,12,22,27-28H,8-9,11,13-14H2,1H3/t22-,23-,24-/m1/s1
    Key: NFXFNBIPWUYEIM-WXFUMESZSA-N
  • CN1CCC23CC4=NC5=CC=CC=C5C=C4CC2(C1CC6=C3C=C(C=C6)O)O
Properties
C24H24N2O2
Molar mass 372.468 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

KNT-127 is an opioid drug selective for the delta opioid receptors.[1] It might be used as an analgesic and anxiolytic.

  1. ^ Yoshioka, Toshinori; Yamada, Daisuke; Segi-Nishida, Eri; Nagase, Hiroshi; Saitoh, Akiyoshi (2023-07-01). "KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model". Neuropharmacology. 232: 109511. doi:10.1016/j.neuropharm.2023.109511. ISSN 1873-7064. PMID 37001727. S2CID 257807312.