KPNB1

KPNB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F59, 1IBR, 1M5N, 1O6O, 1O6P, 1QGK, 1QGR, 2P8Q, 2Q5D, 2QNA, 3LWW, 3W5K
Identifiers
Aliases	KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1
External IDs	OMIM: 602738; MGI: 107532; HomoloGene: 1707; GeneCards: KPNB1; OMA:KPNB1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,685,505 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,078,707 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; ventricular zone; ; ganglionic eminence; ; optic nerve; ; secondary oocyte; ; islet of Langerhans; ; tendon of biceps brachii; ; stromal cell of endometrium; ; internal globus pallidus; ; appendix;
	Top expressed in
	tail of embryo; ; condyle; ; fossa; ; epiblast; ; genital tubercle; ; primitive streak; ; medullary collecting duct; ; abdominal wall; ; ureter; ; ventricular zone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	Hsp90 protein binding; protein domain specific binding; zinc ion binding; protein binding; nuclear localization sequence binding; enzyme binding; RNA binding; importin-alpha family protein binding;
Cellular component	nuclear membrane; membrane; nuclear periphery; nuclear pore; endoplasmic reticulum tubular network; nucleoplasm; extracellular exosome; nucleus; nuclear envelope; extracellular region; cytoplasm; cytosol; specific granule lumen; ficolin-1-rich granule lumen; host cell; cytoplasmic stress granule; protein-containing complex;
Biological process	intracellular transport of virus; apoptotic DNA fragmentation; Ran protein signal transduction; establishment of protein localization; mitotic spindle assembly; protein transport; mitotic metaphase plate congression; intracellular protein transport; astral microtubule organization; mitotic chromosome movement towards spindle pole; establishment of mitotic spindle localization; NLS-bearing protein import into nucleus; modulation by virus of host cellular process; protein import into nucleus; ribosomal protein import into nucleus; viral process; neutrophil degranulation; regulation of cholesterol biosynthetic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	3837
	16211
	ENSG00000108424
	ENSMUSG00000001440
	Q14974
	P70168
	NM_002265; NM_001276453
	NM_008379
	NP_001263382; NP_002256
	NP_032405
	Wikidata
View/Edit Human	View/Edit Mouse

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108424 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001440 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chi NC, Adam EJ, Adam SA (August 1995). "Sequence and characterization of cytoplasmic nuclear protein import factor p97". J. Cell Biol. 130 (2): 265–74. doi:10.1083/jcb.130.2.265. PMC 2199936. PMID 7615630.
^ Görlich D, Kostka S, Kraft R, Dingwall C, Laskey RA, Hartmann E, Prehn S (September 1995). "Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope". Curr. Biol. 5 (4): 383–92. Bibcode:1995CBio....5..383G. doi:10.1016/S0960-9822(95)00079-0. hdl:11858/00-001M-0000-002D-1CBD-2. PMID 7627554. S2CID 6055941.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108424 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001440 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7615630-5] Chi NC, Adam EJ, Adam SA (August 1995). "Sequence and characterization of cytoplasmic nuclear protein import factor p97". J. Cell Biol. 130 (2): 265–74. doi:10.1083/jcb.130.2.265. PMC 2199936. PMID 7615630.

[pmid7627554-6] Görlich D, Kostka S, Kraft R, Dingwall C, Laskey RA, Hartmann E, Prehn S (September 1995). "Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope". Curr. Biol. 5 (4): 383–92. Bibcode:1995CBio....5..383G. doi:10.1016/S0960-9822(95)00079-0. hdl:11858/00-001M-0000-002D-1CBD-2. PMID 7627554. S2CID 6055941.

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