Kaikhosro I Gurieli (Georgian: ქაიხოსრო I გურიელი; died 1660), of the House of Gurieli, was Prince of Guria from 1626 to 1658. He was installed by Levan II Dadiani, Prince of Mingrelia, in place of his deposed predecessor Simon I Gurieli. In his turn, Kaikhosro was overthrown and expelled by King Alexander III of Imereti. His comeback to Guria, in an Ottoman-supported endeavor, concluded with his assassination by a Gurian nobleman.