Karl Friedrich Otto Westphal (23 March 1833 – 27 January 1890) was a German psychiatrist from Berlin. He was the son of Otto Carl Friedrich Westphal (1800–1879) and Karoline Friederike Heine and the father of Alexander Karl Otto Westphal (1863–1941). He was married to Klara, daughter of the banker Alexander Mendelssohn. Westphal died in Kreuzlingen in 1890.