Kendomycin

Kendomycin^[1]
Names
	IUPAC name (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-Trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one
	Systematic IUPAC name (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-Trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one
	Other names (-)-TAN 2162
Identifiers
CAS Number	59785-91-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL523927 ;
ChemSpider	4582118 ;
MeSH	C485395
PubChem CID	5472093;
CompTox Dashboard (EPA)	DTXSID40420223 ;
	InChI InChI=1S/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22,24,28,30,32-33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,24-,28+,29+/m0/s1 Key: HKLDUJXJTQJSEJ-OLXNOMCWSA-N ; InChI=1/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22,24,28,30,32-33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,24-,28+,29+/m0/s1 Key: HKLDUJXJTQJSEJ-OLXNOMCWBE;
	SMILES C[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C3=C(C(=O)C(=C4C3=C[C@@](O4)([C@H](C[C@@H](C/C(=C1)/C)C)C)O)C)O)C)O)C;
Properties
Chemical formula	C29H42O6
Molar mass	486.64 g/mol
Appearance	Yellow powder
Solubility in DMSO, methanol	Soluble
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Toxic
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Kendomycin is an anticancer macrolide first isolated from Streptomyces violaceoruber.^[2] It has potent activity as an endothelin receptor antagonist and anti-osteoporosis agent.^[3] It also has strong cytotoxicity against various tumor cell lines.^[2]

^ Kendomycin Archived 2008-05-16 at the Wayback Machine at Alexis-Biochemicals
^ ^a ^b H B Bode; A Zeeck (2000). "Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces". J. Chem. Soc. Perkin Trans. 1. 323 (3): 323–328. doi:10.1039/a908387a.
^ Burke Research Group Archived 2006-08-29 at the Wayback Machine University of Wisconsin

[1] Kendomycin Archived 2008-05-16 at the Wayback Machine at Alexis-Biochemicals

[Bode-2] H B Bode; A Zeeck (2000). "Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces". J. Chem. Soc. Perkin Trans. 1. 323 (3): 323–328. doi:10.1039/a908387a.

[3] Burke Research Group Archived 2006-08-29 at the Wayback Machine University of Wisconsin

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