Protein found in humans
KRT14 Identifiers Aliases KRT14 , CK14, EBS3, EBS4, K14, NFJ, keratin 14, EBS1D, EBS1, EBS1B, EBS1A, EBS1CExternal IDs OMIM : 148066 ; MGI : 96688 ; HomoloGene : 110439 ; GeneCards : KRT14 ; OMA :KRT14 - orthologs Wikidata
Keratin 14 is a member of the type I keratin family of intermediate filament proteins . Keratin 14 was the first type I keratin sequence determined.[ 5]
Keratin 14 is also known as cytokeratin-14 (CK-14 ) or keratin-14 (KRT14 ). In humans it is encoded by the KRT14 gene .[ 6] [ 7] [ 8]
Keratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells .
^ a b c GRCh38: Ensembl release 89: ENSG00000186847 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045545 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hanukoglu I, Fuchs E (November 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins" . Cell . 31 (1): 243–52. doi :10.1016/0092-8674(82)90424-X . PMID 6186381 . S2CID 35796315 .
^ Coulombe PA, Hutton ME, Letai A, Hebert A, Paller AS, Fuchs E (September 1991). "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses". Cell . 66 (6): 1301–11. doi :10.1016/0092-8674(91)90051-Y . PMID 1717157 . S2CID 11965913 .
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins" . The Journal of Cell Biology . 174 (2): 169–74. doi :10.1083/jcb.200603161 . PMC 2064177 . PMID 16831889 .
^ "Entrez Gene: KRT14 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)" .