Keratolytic winter erythema

Keratolytic winter erythema
Other namesKWE, Erythrokeratolysis hiemalis
Keratolytic Winter erythema has an autosomal dominant pattern of inheritance.

Keratolytic Winter erythema (also known as Oudtshoorn disease[1] or Oudtshoorn skin[2][3]) is a rare autosomal dominant skin disease of unknown cause which causes redness and peeling of the skin on the palms and soles.[4] Onset, increased prominence and severity usually occurs during winter.[5][6] It is a type of genodermatosis.[7]

The name "Oudtshoorn skin" derives from the town of Oudtshoorn in the Western Cape province of South Africa, where the disorder was first described.[5][6] It is one of several genetic disorders known to be highly prevalent among the Afrikaner population.[8]

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ Danielsen, A. G.; Weismann, K.; Thomsen, H. K. (May 2001). "Erythrokeratolysis hiemalis (keratolytic winter erythema): a case report from Denmark". Journal of the European Academy of Dermatology and Venereology. 15 (3): 255–256. doi:10.1046/j.1468-3083.2001.00258.x. ISSN 0926-9959. PMID 11683293. S2CID 12248655.
  3. ^ Findlay, G. H.; Morrison, J. G. L. (May 1978). "Erythrokeratolysis hiemalis--keratolytic winter erythema or 'Oudtshoorn Skin'. A new epidermal genodermatosis with its histological features". The British Journal of Dermatology. 98 (5): 491–495. doi:10.1111/j.1365-2133.1978.tb01934.x. ISSN 0007-0963. PMID 656323. S2CID 44892293.
  4. ^ Appel, S.; Filter, M.; Reis, A.; Hennies, H. C.; Bergheim, A.; Ogilvie, E.; Arndt, S.; Simmons, A.; Lovett, M.; Hide, W.; Ramsay, M. L.; Reichwald, K.; Zimmermann, W.; Rosenthal, A. (January 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". European Journal of Human Genetics. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. ISSN 1018-4813. PMID 11896452.
  5. ^ a b Findlay, N. G.; Nurse, G. T.; Heyl, T.; Hull, P. R.; Jenkins, T.; Klevansky, H.; Morrison, J. G.; Sher, J.; Schulz, E. J.; Swart, E.; Venter, I. J.; Whiting, D. A. (Nov 1977). "Keratolytic winter erythema or 'Oudtshoorn skin': a newly recognized inherited dermatosis prevalent in South Africa". South African Medical Journal (Suid-Afrikaanse Tydskrif vir Geneeskunde). 52 (22): 871–874. ISSN 0256-9574. PMID 607500.
  6. ^ a b Krahl, D.; Sigwart, A.; Hartschuh, W.; Anton-Lamprecht, I.; Petzoldt, D. (Nov 1994). "Erythrokeratolysis hiemalis. Erythematosquamous genetic dermatosis with seasonal manifestation". Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und Verwandte Gebiete. 45 (11): 776–779. doi:10.1007/s001050050170. ISSN 0017-8470. PMID 7822203. S2CID 26456333.
  7. ^ Degiovann CV, F. P.; Farrant, P. B. J.; Howell, S.; Hull, P. R.; Woollons, A. (March 2009). "Keratolytic winter erythema with facial involvement: a novel presentation". Clinical and Experimental Dermatology. 34 (2): 206–208. doi:10.1111/j.1365-2230.2008.02825.x. ISSN 0307-6938. PMID 19018790. S2CID 205276937.
  8. ^ Botha, M. C.; Beighton, P. (Oct 1983). "Inherited disorders in the Afrikaner population of southern Africa. Part II. Skeletal, dermal and haematological conditions; the Afrikaners of Gamkaskloof; demographic considerations". South African Medical Journal. 64 (17): 664–667. ISSN 0256-9574. PMID 6414096.