This article needs more reliable medical references for verification or relies too heavily on primary sources. (April 2016) |
Names | |
---|---|
Preferred IUPAC name
4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one | |
Other names
amicardine, corafurone, methafrone, kelourin, rykellin, visammin; ammispasmin, ammivisnagen, gynokhellan, interkellin, interkhellin, amikellin, ammipuran, benecardin, deltoside, kelicorin, khelangin, khellamine, khellanals, khellinorm, medekellin, visammimix, viscardan, visnagalin, kalangin, kelincor
| |
Identifiers | |
3D model (JSmol)
|
|
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.001.267 |
EC Number |
|
KEGG | |
MeSH | C438920 |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C14H12O5 | |
Molar mass | 260.245 g·mol−1 |
Appearance | colorless needle-shaped crystals |
Melting point | 154-155 C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis.[1] It is a major constituent of the plant Visnaga daucoides, also known as Ammi visnaga and as bishop's weed. Once purified, khellin exists as colorless, odorless, bitter-tasting needle-shaped crystals[2] and is classified as a gamma-pyrone, a furanochromone derivative. In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. A number of drugs were discovered through this research, such as amiodarone and cromolyn sodium, which are used in current medical practice. Efloxate is also mentioned as analog.[3]