Kiko is a given name. It is also used as a nickname for Francisco, for Enrique and for Federico. Notable people with the name include:
- Princess Akishino or Kiko (born 1966), a member of the Japanese imperial family
- Kiko (footballer, born 1972), full name Francisco Miguel Narváez Machón, Spanish retired footballer
- Kiko (footballer, born 1978), full name Josualdo Alves da Silva Oliveira, Brazilian footballer
- Kiko (footballer, born 1988), full name Francisco José Olivas, Spanish footballer
- Kiko (footballer, born 1993), full name Francisco Manuel Geraldo Rosa, Portuguese footballer
- Kiko (footballer, born 1998), full name Francisco Pomares Ortega, Andorran footballer
- Kiko Argüello (born 1939), one of the initiators of the Catholic group Neocatechumenal Way
- Kiko Calero (born 1975), Major League Baseball relief pitcher
- Kiko Casilla (born 1986), Spanish football goalkeeper
- Francisco Femenía (born 1991), Spanish footballer
- Kiko Garcia (born 1953), former Major League Baseball infielder
- Prince Christoph of Hohenlohe-Langenburg (1956-2006), European socialite
- Kiko Loureiro (born 1972), Brazilian heavy metal guitarist
- Federico Macheda (born 1991), Italian footballer
- Kiko Martínez (born 1984), Spanish boxer
- Khaled Mouelhi (born 1981), Tunisian footballer
- Francis Magalona (1964-2009), Filipino rapper sometimes known as "Kiko"
- Francis "Kiko" Pangilinan (born 1963), Filipino senator
- Kiko Amat (born 1971), Spanish writer
- Kiko Ratón (born 1976), Spanish footballer
- Kiko Sánchez (born 1965), Spanish sailor and 1992 Olympic gold medalist
- Kiko Torres (born 1975), Spanish retired footballer
- Kheireddine Zarabi (born 1984), Algerian footballer
- Kiko Mizuhara (born 1990), American/Japanese actress and model
- Kiko Alonso (born 1990), American football linebacker
- Kiko Yokota (born 1997), Japanese rhythmic gymnast
- Kiko Merley (born 1997), American music producer and member of Brockhampton
- Lolo Kiko, a nickname given by Filipinos to Pope Francis during his visit to the Philippines in 2015